2010 NFL draft

The 2010 NFL draft was the 75th annual meeting of National Football League (NFL) franchises to select newly eligible football players. The 2010 draft took place over three days, at Radio City Music Hall in New York City, with the first round on April 22, 2010. The second and third rounds took place on April 23, while the final four rounds were held on April 24. Television coverage was provided by both NFL Network and ESPN.

The St. Louis Rams, as the team with the worst record during the 2009 season, selected the 2008 Oklahoma Sooners football Heisman Trophy-winning quarterback Sam Bradford with the first pick in the draft. Three of the top four picks–Bradford, defensive tackle Gerald McCoy, and offensive tackle Trent Williams–were members of the Oklahoma Sooners football team, and five of the top six–Bradford, Nebraska defensive tackle Ndamukong Suh, McCoy, Williams, and Oklahoma State offensive tackle Russell Okung–were from the Big 12 Conference. The Detroit Lions made the final pick in the draft, commonly called Mr. Irrelevant, by selecting the FCS first-team All-American wide receiver out of Weber State Tim Toone with the two-hundred and fifty-fifth pick. The prime-time broadcast of the first round was watched by 7.29 million viewers making it the most viewed first round ever and making ESPN the second most watched network of the night.

As of 2026, the only remaining active players from the 2010 draft class are San Francisco 49ers offensive tackle Trent Williams, Philadelphia Eagles defensive end Brandon Graham, Tennessee Titans long snapper Morgan Cox, and free agents defensive end Jerry Hughes and defensive tackle Linval Joseph, who have both last played for both of the league's Texas-based teams in 2024, the Houston Texans and the Dallas Cowboys, respectfully.