2010 Mutua Madrileña Madrid Open – Men's singles
| Men's singles | |
|---|---|
| 2010 Mutua Madrileña Madrid Open | |
| Champion | Rafael Nadal |
| Runner-up | Roger Federer |
| Score | 6–4, 7–6(7–5) |
Rafael Nadal defeated the defending champion Roger Federer in a rematch of the previous year's final, 6–4, 7–6(7–5) to win the men's singles tennis title at the 2010 Madrid Open.
This tournament marked the final professional appearance of former world No. 1, 1998 French Open and three-time Masters champion Carlos Moyá; he lost in the first round to Benjamin Becker.