2001 US Open – Men's singles

Lleyton Hewitt defeated Pete Sampras in the final, 7–6^(7–4), 6–1, 6–1 to win the men's singles tennis title at the 2001 US Open. It was his first major singles title. Hewitt was the first millennial male player to win a major title.

Marat Safin was the defending champion, but lost in the semifinals to Sampras in a rematch of the previous year's final.

This was the last major appearance of former world No. 1 and two-time US Open champion Pat Rafter; he lost in the fourth round to Sampras. This was also the last major appearance of two-time French Open champion and former world No. 3 Sergi Bruguera; he lost in the first round to Christophe Rochus. This was the first major main draw appearance of future Tour Finals champion David Nalbandian.

The high-profile quarterfinal match between Sampras and Andre Agassi was an all-time classic, and saw Sampras and Agassi hold serve in every one of their 24 service games each. The match had no breaks of serve, and ended with Sampras winning 6–7^(7–9), 7–6^(7–2), 7–6^(7–2), 7–6^(7–5).

This was the first time the US Open used 32 seeds instead of 16, in order to better spread out the higher ranked players.