2-Aminofluorene

2-Aminofluorene
Structure of 2-aminofluorene
Names
Systematic IUPAC name
9H-Fluoren-2-amine
Other names
2-Fluorenamine; 2-fluoreneamine
Identifiers
3D model (JSmol)
Abbreviations 2-AF
ChEMBL
ChemSpider
ECHA InfoCard 100.005.290
EC Number
  • 205-817-8
UNII
UN number 2811
  • InChI=1S/C13H11N/c14-11-5-6-13-10(8-11)7-9-3-1-2-4-12(9)13/h1-6,8H,7,14H2
    Key: CFRFHWQYWJMEJN-UHFFFAOYSA-N
  • c1cccc3c1c2c(cc(N)cc2)C3
Properties
C13H11N
Molar mass 181.238 g·mol−1
Appearance White to tan solid
Melting point 125–132 °C (257–270 °F; 398–405 K)
<.1 g/100 mL at 19.5 °C
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
Cytotoxic
GHS labelling:
Warning
H341, H351
P201, P280, P308+P313
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

2-Aminofluorene (2-AF) is a synthetic arylamine. It is a white to tan solid with a melting point of 125-132 °C. 2-AF has only been tested in controlled laboratory settings thus far. There is no indication that it will be tested in industrialized settings. There is evidence that 2-aminofluorene is a carcinogen and an intercalating agent that is extremely dangerous to genomic DNA that potentially can lead to mutation if not death. Furthermore, it has been suggested that 2-aminofluorene can undergo acetylation reactions that causes these reactive species to undergo such reactions in cells. Several experiments have been conducted that have suggested 2-aminofluorene be treated with care and with an overall awareness of the toxicity of this compound.