1S-LSD

1S-LSD
Clinical data
Other names	1-(3-(Trimethylsilyl)propionyl)-LSD; 1-[3-(Trimethylsilyl)propanoyl]-LSD; (8β)-1-(3-(Trimethylsilyl)propionyl)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide; X-LSD
Routes of; administration	Oral, Sublingual
Drug class	Serotonergic psychedelic; Hallucinogen
ATC code	None;
Legal status
Legal status	DE: NpSG (Industrial and scientific use only);
Identifiers
	IUPAC name (6aR,9R)-N,N-diethyl-7-methyl-4-(3-trimethylsilylpropanoyl)-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide;
PubChem CID	172875719;
Chemical and physical data
Formula	C26H37N3O2Si
Molar mass	451.686 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[Si](CCC(=O)N1C=C2C[C@H]3N(C[C@@H](C=C3C=3C=CC=C1C32)C(=O)N(CC)CC)C)(C)C;
	InChI InChI=1S/C26H37N3O2Si/c1-7-28(8-2)26(31)19-14-21-20-10-9-11-22-25(20)18(15-23(21)27(3)16-19)17-29(22)24(30)12-13-32(4,5)6/h9-11,14,17,19,23H,7-8,12-13,15-16H2,1-6H3/t19-,23-/m1/s1; Key:RYNRSMKGPSUXLC-AUSIDOKSSA-N;

1S-LSD, also known as 1-(3-(trimethylsilyl)propionyl)-LSD, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). It is the trimethylsilyl derivative of 1P-LSD and functions as a prodrug and functional analogue of LSD. 1S-LSD was developed in response to legal restrictions on similar compounds, such as 1D-LSD, which were banned in Germany under the NpSG law in June 2024.

The compound was introduced as a legal alternative by incorporating a trimethylsilyl group, which is not covered under current NpSG regulations. This chemical modification allows 1S-LSD to be legally sold in Germany as of September 2024. It is typically distributed in its hemi-D-tartrate form, a common format for lysergamides due to its stability and ease of use.