1964 Houston Colt .45s season

The 1964 Houston Colt .45s season was the third season for the Major League Baseball (MLB) franchise located in Houston, Texas, a member of the National League (NL) based at Colt Stadium, The Colt .45s entered the season with a 66–96 record, in ninth place and 33 games behind the NL pennant and World Series-winning Los Angeles Dodgers.

The Colt .45s commenced their season on April 13, hosted by the Cincinnati Reds at Crosley Field, where Ken Johnson made the Opening Day start for the Astros, who won, 6–3. On April 19, right-hander Bob Bruce delivered the first-ever immaculate inning for Houston.

Ten days after the season started, on April 23, Ken Johnson hurled the second no-hitter in franchise history. However, he became the first pitcher in major league history to lose a complete game no-hitter in nine innings, a 1–0 defeat to Cincinnati.

Pitcher Turk Farrell represented the Colt .45s for the MLB All-Star Game, his fourth career selection.

Manager Harry Craft was terminated on September 19 and replaced by bench coach Lum Harris. The final game at Colt Stadium was hosted on September 27, a 1–0, 12-inning victory over Los Angeles. Jimmy Wynn delivered the final, walk-off hit, while starter Bob Bruce earned the victory via a complete game shutout.

The Colt .45s concluded the 1964 season with a 66–96 record, in ninth place and 27 games behind the NL pennant and eventual World Series champion St. Louis Cardinals. This was the final of three seasons in which Houston played as the Colt .45s and at Colt Stadium before being renamed the Astros and relocating to The Astrodome effective the following year.