β,N,N-Trimethylphenethylamine

β,N,N-Trimethylphenethylamine, also known as N,N-dimethyl-2-phenylpropan-1-amine (N,N-DMPPA or DMPPA) is a monoamine releasing agent of the phenethylamine family. It is the N-methyl derivative of phenpromethamine (β,N-methylphenethylamine) and the N,N-dimethyl derivative of β-methylphenethylamine. The drug is a partial norepinephrine releasing agent, with an EC₅₀Tooltip half-maximal effective concentration of 1,337 nM and an E_maxTooltip maximal efficacy of 67% in rat brain synaptosomes. Conversely, it was inactive on dopamine, whereas serotonin was not reported. The drug produces non-significant increases in blood pressure in rodents, but does not affect heart rate or affect locomotor activity. It may be rapidly metabolized and thereby inactivated. DMPPA was first described in the scientific literature by at least 2019.